Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity

One new secoiridoid compound swertiamarin B (1), along with a known compound lytanthosalin (2), were isolated from ethanol extract of the aerial parts of Swertia mussotii. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were first isolated from the Swertia genus. Their antitumor activities were evaluated for four human tumor cell lines (HCT-116, HepG2, MGC-803 and A549). Compounds 1 and 2 showed excellent cytotoxic activities toward the MGC-803 cell lines with IC50 values 3.61 and 12.04 mu M, respectively.

Automated summary

A new secoiridoid compound and a known compound were isolated from the ethanol extract of Swertia mussotii, showing excellent cytotoxic activities towards the MGC-803 cell lines. These compounds were first isolated from the Swertia genus and their antitumor activities were evaluated for four human tumor cell lines.