Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 9, Pages 1561-1565Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1656624
Keywords
Mangrove endophytic fungi; Bruguiera sexangula; Phyllosticta capitalensis; meroterpenes; polyketides; antimicrobial activity
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Funding
- National Natural Science Foundation of China [81973229, 81660584]
- Innovative Research Team grant from the Natural Science Foundation of Hainan University [hdkytg201705]
- collaborative innovation fund joint project of Tianjin University Hainan University [HDTDU201902]
- Key Project of Education Department of Hainan Province [Hnky2019ZD-6]
- Key lab of tropical pharmaceutical herb chemistry of Hainan province Open Fund in Hainan Normal University [RDZH2019004]
- Hainan Provincial Graduate Innovation Research Project [Hyb2018-11]
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Chemical investigation of the endophytic fungus Phyllosticta capitalensis isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, whose structures were elucidated and subjected to antimicrobial and cytotoxic activities evaluation. This is the first report of these compounds being isolated from this fungal species.
Chemical investigation of endophytic fungus Phyllosticta capitalensis, isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, including four meroterpenes guignardone A (1), 12-hydroxylated guignardone A (2), guignardone J (3), guignardone M (4), and four polyketides xenofuranone B (5), 6,8-dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (6), regiolone (7), 3,4-dihydroxybenzoic acid (8). Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. This is the first report of these compounds being isolated from this fungal species. All compounds isolated were subjected to antimicrobial and cytotoxic activities evaluation.
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