Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 16, Pages 2784-2788Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1666386
Keywords
Harmine; alkaloid extract; NMR spectroscopy; structure elucidation; sesquiterpenes; antioxidant and anti-acetylcholinesterase activities; Lycium europaeum L
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Funding
- Ministry of Higher Education and Scientific Research of Algeria [D01N01UN310120140007]
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The phytochemical investigation of Lycium europaeum L. revealed the presence of alkaloids and sesquiterpenes with antioxidant and AChE inhibitory activities. The ethanolic and alkaloid extracts from roots and leaves showed promising results in bioautography assays, particularly the alkaloid extracts demonstrated the strongest activity against oxidation and AChE.
Lycium europaeum L. is a spiny shrub of the Solanaceae family, known in Algeria as 'Awsaj' and used as food and herbal remedy. The phytochemical investigation of the alkaloid extract of roots and leaves led to the isolation and characterisation of one alkaloid (harmine (3)) and four sesquiterpenes (C-1 ' epimer of (2 R,5S,10R)-2-(1 ',2 '-dihydroxy-1 '-methylethyl)-6,10-dimethylspiro[4,5]dec-6-en-8-one (1), C-1 ' epimer of 2-(1 ',2 '-di-hydroxy-1 '-methylethyl)-6,10-dimethylspiro[4,5]dec-6,9-dien-8-one (2), (+)-dehydrovomifoliol (4), vomifoliol (5)). Their structures were elucidated using NMR and MS spectroscopic data. The isolated compounds were characterised for the first time from the genus Lycium. All isolated compounds have shown antioxidant and acetylcholinesterase (AChE) inhibitory activities in the bioautography assays. The ethanolic and alkaloid extracts of roots and leaves were also tested, and, particularly, the alkaloid extracts were the most active ones as antioxidant and AChE inhibitors.
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