Journal
NANOMEDICINE
Volume 14, Issue 22, Pages 2925-2939Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0255
Keywords
Aurantii fructus immaturus; bioactivity; carbon dots; gouty arthritis; hyperuricemia; inflammation; monosodium urate crystals; pro-inflammatory cytokine; uric acid; xanthine oxidase
Funding
- National Natural Science Foundation of China [81573573]
- Foundation for the New teachers program of the Beijing University of Chinese Medicine [2019-JYB-XJSJJ044]
- Scientific Research and Innovation Team Project [2019-JYB-TD-001]
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Aim: To explore the antihyperuricemia and anti-gouty arthritis activities of Aurantii fructus immaturus carbonisata-derived carbon dots (AFIC-CDs). Materials & methods: The AFIC-CDs were characterized using transmission electron microscopy; high-resolution transmission electron microscopy; ultraviolet, fluorescence, Fourier-transform infrared and x-ray photoelectron spectroscopy; high-performance liquid chromatography; and x-ray diffraction. Antihyperuricemia and anti-gouty arthritis activities of AFIC-CDs were explored in vivo and in vitro. Results: The AFIC-CDs diameter ranged from 1.1 to 4.4 nm, with a yield of 7.2%. AFIC-CDs reduced serum uric acid by inhibiting xanthine oxidase activity in hyperuricemia rats and inhibited xanthine oxidase activity in vitro. AFIC-CDs improved gouty arthritis induced by monosodium urate crystals in vivo and in vitro. Conclusion: AFIC-CDs may be a potential treatment for gout.
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