Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 2, Pages 266-269Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.11.054
Keywords
Chrysanthemum indicum; Chrysannol A; NO; TNF-alpha; Anti-inflammation
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea [2009-0093815]
- Korea Food and Drug Administration for Studies on Standardization of Herbal Medicine
- Ministry of Knowledge Economy (MKE)
- Korea Institute for Advancement of Technology (KIAT) through the Inter-ER Cooperation Projects [R0002019]
- Korea Evaluation Institute of Industrial Technology (KEIT) [R0002019] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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One new octulosonic acid derivative, chrysannol A (1), along with 17 known compounds (2-18), were isolated from Chrysanthemum indicum flowers. Their structures were determined from 1D NMR, 2D NMR, HR-ESI-MS spectral data, and comparisons with previous reports. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) production by RAW 264.7 cells were investigated. Compound 8 showed the highest inhibition of NO production of 46.09% at a concentration of 10.0 mu M. Compounds 7, 10, 11, and 16 inhibited TNF-alpha secretion at all concentration tested (0.4, 2.0, and 10.0 mu M), with inhibition values ranging from 22.27% to 33.13%. In addition, compound 8 and 9 decrease COX-2 and iNOS protein on Western blot analysis in dose dependent manner. (C) 2014 Elsevier Ltd. All rights reserved.
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