Journal
MOLECULES
Volume 24, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/molecules24193536
Keywords
Angelica sinensis; geoherb region; chemical markers; content; UHPLC-QTOF-MS; MS; metabolomics; anti-inflammation; calcium antagonists
Funding
- National Key RAMP
- D Program of China [2016YFE0129000]
- Key RAMP
- D Program of Tianjin [18YFYZCG00060]
- Research Project of Gansu Provincial Administration of Traditional Chinese Medicine [GZK-2015-21]
- Fundamental Research Funds for the Central Universities [lzujbky-2017-k26]
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This research aimed to discover chemical markers for discriminating radix Angelica sinensis (RAS) from different regions and to explore the differences of RAS in the content of four active compounds and anti-inflammatory activities on lipopolysacchride (LPS)-induced RAW264.7 cells and calcium antagonists on the HEK 293T cells of RAS. Nine compounds were selected as characteristic chemical markers by ultra-high-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS), based on metabolomics, in order to rapidly discriminate RAS from geoherb and non-geoherb regions. The contents of senkyunolide I and butylidenephthalide in geoherb samples were higher than those in non-geoherb samples, but the contents of ferulic acid and levistolide A were lower in the geoherb samples. Furthermore, the geoherbs showed better nitric oxide (NO) inhibitory and calcium antagonistic activities than the non-geoherbs. These results demonstrate the diversity in quality of RAS between geoherbs and non-geoherbs.
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