Journal
MOLECULES
Volume 24, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/molecules24173062
Keywords
Diaporthe phaseolorum; deep-sea derived fungus; polyketides; cytotoxicity
Funding
- National Natural Science Foundation of China [41906106]
- Science and Technology Program of Guangzhou, China [201607020018]
- Natural Science Foundation of Guangdong Province [2016A030312014]
- GDAS' Project of Science and Technology Development [2019GDASYL-0103007]
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Two new chromone-derived polyketides phaseolorins, G and H (1 and 2), and one new anthraquinone derivative, phaseolorin I (3), together with three known compounds (4-6), were isolated from the deep-sea sediment-derived fungus Diaporthe phaseolorum FS431. The structures of the new compounds were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electron capture detection (ECD). All the isolated compounds (1-6) were tested for their in vitro cytotoxic activities against four human tumor cell lines, of which compound 4 exhibited significant effect against MCF-7, HepG-2, and A549 tumor cell lines with IC50 values of 2.60, 2.55, and 4.64 mu M, respectively.
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