Journal
MOLECULAR BIOLOGY REPORTS
Volume 46, Issue 6, Pages 6647-6659Publisher
SPRINGER
DOI: 10.1007/s11033-019-05066-1
Keywords
Flavonoid; Metabolic engineering; Escherichia coli; Saccharomyces cerevisiae; Streptomyces sp.
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Funding
- Special Allocation for Agencies Under Academy of Sciences Malaysia-Ministry of Science, Technology and Innovation Grant [PKA0514F004, 6300824]
- Putra Graduate Initiative, Universiti Putra Malaysia [GP/IPS/2016/9482200]
- Jabatan Perkhidmatan Awam (JPA) Malaysia
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Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds.
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