Journal
MICROCHIMICA ACTA
Volume 186, Issue 9, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-019-3761-6
Keywords
Reduced graphene oxide; Gold nanoparticles; Poly 2-amino-5-mercapto-1,3,4-thiadiazole; Doxorubicin; Electrochemical sensor
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Funding
- Iran University of Medical Sciences
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A nanocomposite was prepared with reduced graphene oxide, gold nanoparticles and an electropolymerized film made from 2-amino-5-mercapto-1,3,4-thiadiazole. An electrochemical sensor for doxorubicin (DOX) was constructed by modifying a glassy carbon electrode (GCE) with the nanocomposite. The modified GCE was studied by electrochemical techniques which showed it to enable highly sensitive sensing of DOX. Response (typically measured at a typical working potential of -0.56 V vs. Ag/AgCl) is linear in the 30 pM to 30 nM and 30 nM to 30 mu M DOX concentration ranges, with a limit of detection (LOD) of 9 pM (at an S/N ratio of 3). The method was applied to the determination of DOX in serum and gave recoveries that ranged between 92 and 108%.
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