Journal
MEDICINAL CHEMISTRY
Volume 17, Issue 1, Pages 71-84Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406415666190904143852
Keywords
Antibacterial agents; antimicrobial; fluoroquinolone; amino acid; conjugates; molecular modeling
Categories
Funding
- Egyptian Cultural and Educational Bureau Scholarship
- Center for Undergraduate Research and Scholarship (CURS) at Augusta University
- Translational Research Program (TRP) at Augusta University
Ask authors/readers for more resources
This study aimed to synthesize and evaluate new fluoroquinolone-3-carboxamide amino acid conjugates as novel antibacterial agents, demonstrating strong selectivity against E. Coli. Additionally, the experimental results showed that the protecting groups on amino acids reduce antibacterial activity, but the synthesized conjugates are non-toxic to normal cell lines.
Background: Bacterial infections are considered as one of the major global health threats, so it is very essential to design and develop new antibacterial agents to overcome the drawbacks of existing antibacterial agents. Methods: The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize the desired hybrid conjugates. Results: All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial activity. The compounds were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 19433). Conclusion: The observed antibacterial experimental data indicates the selectivity of our synthesized conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data were supported by computational studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available