4.5 Article

Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia

Journal

MEDICAL MYCOLOGY
Volume 58, Issue 4, Pages 560-563

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/mmy/myz090

Keywords

Talaromyces atroroseus; Talaromyces marneffei; Indonesia; ITS; BenA

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We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37 degrees C. Based on molecular analysis, nine isolates were identified as Talaromyces atroroseus (including the isolates from rats) and one as T. marneffei. Our susceptibility result of T. marneffei supports the use of amphotericin B, itraconazole for talaromycosis marneffei management. Talaromyces atroroseus showed variable MIC to echinocandin, azole derivatives, 5-flucytosine and amphotericin B.

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