Journal
MEDICAL CLINICS OF NORTH AMERICA
Volume 103, Issue 5, Pages 821-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2019.05.004
Keywords
Antiarrhythmic therapy; Cardiac action potential; Mechanisms of arrhythmia; Practical approach to antiarrhythmics
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The narrow therapeutic window of antiarrhythmic drugs makes their use clinically challenging. A solid understanding of the mechanisms of arrhythmias and how antiarrhythmics affect these mechanisms is only a preliminary step in their appropriate selection. Clinical factors, side-effect profiles, and proarrhythmic risks are more important than the cellular mechanisms of actions in drug selection and monitoring. This article provides a simplified approach to understanding cellular mechanisms and provides a practical approach to the selection and use of this important class of medications.
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