Journal
AUTOIMMUNITY REVIEWS
Volume 15, Issue 12, Pages 1171-1180Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2016.09.003
Keywords
MicroRNAs (miRs); Systemic lupus erythematosus (SLE); Primary Sjogren's syndrome (SS); Rheumatoid arthritis (RA); Systemic sclerosis (SSc); Multiple sclerosis (MS); Psoriasis
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Funding
- Hungarian National Scientific Research Fund (OTKA) Grant [K101470]
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MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential in regulating gene expression, cell development, differentiation and function. Autoimmune diseases are a family of chronic systemic inflammatory diseases. Recent findings on miRNA expression profiles have been suggesting their role as biomarkers in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome. In this review, we summarize the characteristics of miRNAs and their functional role in the immune system and autoimmune diseases including systemic lupus erythematosus, primary Sjogren's syndrome, rheumatoid arthritis, systemic sclerosis, multiple sclerosis and psoriasis; moreover, we depict the advantages of miRNAs in modern diagnostics. (C) 2016 Elsevier B.V. All rights reserved.
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