Journal
AUTOIMMUNITY REVIEWS
Volume 15, Issue 1, Pages 50-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2015.08.011
Keywords
Antiphospholipid syndrome; Anti-beta 2 glycoprotein I antibody; Dendritic cell; Autoreactive T-cell; Monocyte; Neutrophil
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The antiphospholipid syndrome (APS) is a systemic autoimmune disease that is characterized serologically by the presence of antiphospholipid antibodies (aPL) and clinically by vascular thrombosis and obstetric complications. The protein beta 2 glycoprotein I (beta 2GPI) is identified as the most important autoantigen in this syndrome. Activation of endothelial cells, thrombocytes and placental tissue by anti-beta 2GPI antibodies relates to the clinical manifestations of APS. This review describes genetic and environmental factors in relation to APS and summarizes the current knowledge on abnormalities in components of both the innate and adaptive immune system in APS. The role of dendritic cells, T-cells, B-cells, monocytes, neutrophils and NK-cells as well as the complement system in APS are discussed. Several gaps in our knowledge on the pathophysiology of APS are identified and a plea is made for future extensive immune cell profiling by a systems medicine approach in order to better unravel the pathogenesis of APS, to gain more insight in the role of the immune system in APS as well as having the potential to reveal biomarkers or novel therapeutic targets. (C) 2015 Elsevier B.V. All rights reserved.
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