Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 107, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110197
Keywords
Spider silk; Linothele megatheloides; Bombyx most silk; Natural polymer; Cell adhesion; Bioactivity
Categories
Funding
- REMIX - European Union [778078]
- European Commission [785219, 732344]
- Italian Ministry of Education, University and Research (MIUR), under the Departments of Excellence grant [L. 232/2016, ARS01-01384-PROSCAN, PRIN-2017TTP3S]
- Marie Curie Actions (MSCA) [778078] Funding Source: Marie Curie Actions (MSCA)
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Silks, in particular silkworm silks, have been studied for decades as possible candidate materials for biomedical applications. Recently, great attentions have been paid to spider silks, mainly due to their unique and remarkable mechanical properties. Both materials express singular interactions with cells through specific biorecognition moieties on the core proteins making up the two silks. In this work, the silk from a Colombian spider, Linothele megadieloides (LM), which produces a single type of silk in a relatively large amount, was studied in comparison with silk from Bombyx mod silkworm, before and after degumming, with the evaluation of their chemical, mechanical and biological properties. Unexpected biological features in cell culture tests were found for the LM silk already at very early stage, so suggesting further investigation to explore its use for tailored biomedical applications.
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