Mesoporous carriers for transdermal delivery of antifungal drug

Immobilization of antifungal drugs into various nano- and submicron carriers is a perspective way to overcome such limitations associated with their application as high toxicity and unfavorable physicochemical properties. The current study introduces a novel formulation for the poor soluble antimicotic drug. Griseofulvin, which is based on mesoporous calcium carbonate particles offering enhanced loading capacity and bioavailability. Proposed particulate system provides delivery and accumulation into the skin that reveals promising outlook for topical antifungal treatment providing targeted delivery to the lesion area of skin. (C) 2019 Published by Elsevier B.V.