Journal
MARINE DRUGS
Volume 17, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/md17100562
Keywords
siderophores; marine microbes; synthesis; biosynthesis
Categories
Funding
- National Natural Science Foundation of China [81773628, 41776139]
- National Key R & D Program of China [2017YFE0103100, 2018YFC0311003]
- 111-National Overseas Expertise Introduction Center for Green Pharmaceutical Discipline Innovation [D17012]
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Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes.
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