Journal
MARINE DRUGS
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md17080482
Keywords
deep-sea sediment; marine yeast-like fungi; Cystobasidium laryngis; phenazine derivatives; saphenic acid; anti-inflammatory activity
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Funding
- Ministry of Oceans and Fisheries, Korea [20170411]
- [PE99752]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [201704112] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Three new phenazine derivatives (1-3), along with known compounds (4-7) of saphenic acid derivatives, were isolated from a deep-sea sediment-derived yeast-like fungus Cystobasidium larynigs collected from the Indian Ocean. The structures of the new compounds (1-3) were determined by analysis of spectroscopic data, semi-synthesis and comparison of optical rotation values. All the isolated compounds (1-7), except for 2, showed nitric oxide (NO) production inhibitory effect against lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells without cytotoxicity at concentrations up to 30 mu g/mL. This is the first report on the yeast-like fungus Cystobasidium laryngis producing phenazines and anti-inflammatory activity of 1-7 including saphenic acid (4).
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