Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 19, Pages 4114-4117Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.08.027
Keywords
Disulfide cleavage; Tris-(hydroxypropyl) phosphine; Aqueous chemistry; Cystine derivative; Thiols
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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Tris(3-hydroxypropyl) phosphine (THPP) is demonstrated to be a versatile, water-soluble and air-stable reducing agent, allowing for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous-organic media. The reagent shows exceptional stability at biological pH under which condition it permits the rapid reduction of a wide range of differentially functionalized small-molecule disulfides. (C) 2015 Elsevier Ltd. All rights reserved.
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