Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 2, Pages 172-174Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.12.005
Keywords
Boron neutron capture therapy (BNCT); Boron nitride nanotubes (BNNTs); Antitumor effect; B16 melanoma cells; Colony-forming assay
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Funding
- Ministry of Education, Science, Sports, Culture and Technology from Japan [26293007]
- Grants-in-Aid for Scientific Research [26293007] Funding Source: KAKEN
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The first BNCT antitumor effects of BNNTs toward B16 melanoma cells were demonstrated. The use of DSPE-PEG2000 was effective for preparation of the BNNT-suspended aqueous solution. BNNT-DSPE-PEG2000 accumulated in B16 melanoma cells approximately three times higher than BSH and the higher BNCT antitumor effect was observed in the cells treated with BNNT-DSPE-PEG2000 compared to those treated with BSH, indicating that BNNT-DSPE-PEG2000 would be a possible candidate as a boron delivery vehicle for BNCT. (C) 2014 Elsevier Ltd. All rights reserved.
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