Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 8, Pages 1742-1746Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.02.074
Keywords
Glycyrrhizic acid; Derivatives; Analogs; Influenza A/H1N1 virus; Antivirals
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Funding
- Russian Science Foundation [14-03-01307]
- Russian Science Foundation [14-13-01307] Funding Source: Russian Science Foundation
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This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with L-amino acids or their methyl esters, and amino sugar (D-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI = 61 and 38), and S-benzyl-cysteine (SI = 71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents. (C) 2015 Elsevier Ltd. All rights reserved.
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