Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 20, Issue 10, Pages 781-792Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1900073
Keywords
Gut microbiota; Bile acid; Farnesoid X receptor; Vitamin D receptor; Metabolism
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Funding
- National Key Research and Development Program of China [2016YFA0501602]
- National Natural Science Foundation of China [61801108, 81801478]
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Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. Bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial-host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.
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