Journal
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
Volume 42, Issue 5, Pages 580-584Publisher
WILEY
DOI: 10.1111/jvp.12797
Keywords
pharmacokinetics; piglets; sodium baicalin
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Funding
- National Key R&D Program of China [2016YFD0501307]
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The purpose of this study was to determine the pharmacokinetics of baicalin after intravenous and intramuscular administration of sodium baicalin at 50 mg/kg to piglets. Plasma baicalin levels were determined by high-performance liquid chromatography. The plasma concentration-time data of baicalin for both administration routes were best described by two-compartmental open model. The area under the plasma concentration-time curve and the elimination half-lives were 77.47 +/- 6.14 mu g/ml x h and 1.73 +/- 0.16 hr for intravenous and 64.85 +/- 5.67 mu g/ml x h and 2.42 +/- 0.15 hr for intramuscular administration, respectively. The apparent volume of distribution and body clearance were 1.63 +/- 0.23 L/kg and 2.74 +/- 0.30 L h(-1) kg(-1) for intravenous and 0.51 +/- 0.10 L/kg and 0.78 +/- 0.08 L h(-1) kg(-1) for intramuscular routes, respectively. An intramuscular injection of sodium baicalin in piglets resulted in rapid and complete absorption, with a mean maximal plasma concentration of 77.28 +/- 7.40 mu g/ml at 0.17 hr and a high absolute bioavailability of 83.73 +/- 5.53%.
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