Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 36, Pages 14306-14316Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b06500
Keywords
-
Categories
Funding
- European Union [279313, 714122]
- FEDER/Ministerio de Ciencia, Innovacion y Universidades Agencia Estatal de Investigacion [RTI2018-095618-B-100, CTP2016-80206-P, CTQ2017-89814-P, CTQ2017-83486-P]
- Generalitat de Catalunya [2017-SGR-1406]
- CERCA Programme/Generalitat de Catalunya
- MINECO [BES-2014-067825, CTQ2013-48396-P]
- National Science Foundation-CAREER [1352201]
- La Caixa Foundation
- C3UPO
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1352201] Funding Source: National Science Foundation
Ask authors/readers for more resources
Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification due to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture, and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here, we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available