Journal
JOURNAL OF RHEUMATOLOGY
Volume 47, Issue 5, Pages 739-747Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.190186
Keywords
CHRONIC NONBACTERIAL OSTEOMYELITIS; SCORING TOOL; INTERRATER RELIABILITY; MAGNETIC RESONANCE IMAGING
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Funding
- Childhood Arthritis and Rheumatology Research Alliance-Arthritis Foundation
- US National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01AR059703]
- Clinical Research Scholar Program from Seattle Children's Research Institute
- Oak Foundation [OCAY-13-309]
- Bristol-Myers Squibb
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Objective. Serial magnetic resonance imaging (MRI) examinations are often needed in chronic nonbacterial osteomyelitis (CNO) to determine the objective response to treatment. Our objectives in this study were (1) to develop a consensus-based MRI scoring tool for clinical and research use in CNO; and (2) to evaluate interrater reliability and agreement using whole-body (WB)-MRI from children with CNO. Methods. Eleven pediatric radiologists discussed definitions and grading of signal intensity, size of signal abnormality within bone marrow, and associated features on MRI through monthly conference calls and a consensus meeting, using a nominal group technique in July 2017. WB-MRI scans from children with CNO were deidentified for training reading and an interrater reliability study. The reading by each radiologist was conducted in a randomized order. Interrater reliability for abnormal signal and severity were assessed using free-marginal. statistics. Results. Radiologists reached a consensus on grading CNO-specific MRI findings and on describing bone units based on anatomy. A total of 45 sets of WB-MRI scans, including 4 sets of non-CNO MRI examinations, were selected for the final reading. The mean. of each category of bones was > 0.7 with majority > 0.9 demonstrating substantial/almost perfect interrater reliability of readings among radiologists. The agreement on signal intensity and the size of signal abnormality within the most commonly affected bones (femur and tibia) were lower than those of other bones. Conclusion. The chronic nonbacterial osteomyelitis magnetic resonance imaging scoring (CROMRIS) tool is a comprehensive standardized scoring tool for MRI in children with CNO. Our interrater study demonstrated good interrater reliability and agreement of readings.
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