Journal
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 23, Issue 11-12, Pages 1159-1183Publisher
WORLD SCI PUBL CO INC
DOI: 10.1142/S1088424619501268
Keywords
BODIPYs; aza-BODIPYs; in vivo imaging; theranostics
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Funding
- Universite de Bourgogne
- Conseil Regional de Bourgogne Franche-Comte through the plan d'actions regional pour l'innovation (PARI)
- European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs
- French Research National Agency (ANR) via project JCJC SPID [ANR-16-CE07-0020, ANR-18-CE18-0012]
- French Research National Agency (ANR) via project JCJC WazaBY [ANR-18-CE18-0012]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE18-0012] Funding Source: Agence Nationale de la Recherche (ANR)
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Since their discovery in 1968, the BODIPYs dyes (4,4-difluoro-4-bora-3a, 4a diaza-s-indacene) have found an exponentially increasing number of applications in a large variety of scientific fields. In particular, studies reporting bioapplications of BODIPYs have increased dramatically. However, most of the time, only in vitro investigations have been reported. The in vivo potential of BODIPYs and aza-BODIPYs is more recent, but considering the number of in vivo studies with BODIPY and aza-BODIPY which have been reported in the last five years, we can now affirm that this family of fluorophores can be considered important as cyanine dyes for future in vivo and even clinical applications. This review aims to present representative examples of recent in vivo applications of BODIPYs or aza-BODIPYs, and to highlight the potential of these dyes for optical molecular imaging.
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