Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 141, Issue 1, Pages 83-85Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2019.09.008
Keywords
Cerebral stroke; Inflammation; Barrier function
Categories
Funding
- R&D, Research Competitiveness Subprogram (RCS) of the Louisiana Board of Regents through the Board of Regents Support Fund [LEQSF(2019-22)-RD-A-26]
- National Institute of General Medical Sciences of the National Institute of Health [5P20GM103424-15, 3P20GM10342415S1]
- Malcolm Feist PAC Seed Program, Center for Cardiovascular Diseases and Sciences, LSU Health Shreveport
- Faculty Research Support Program Award from the College of Pharmacy, University of Louisiana Monroe
Ask authors/readers for more resources
Dysregulation of the blood brain barrier due to oxidative stress causes neurological disorders, such as Alzheimer's and Parkinson's disease. We employed brain microvascular endothelial cells; to investigate the effects of P53 towards the lipid oxidation of the BBB. P53 reduction by LPS, siRNA for P53 and Pifithrin increased the expression levels of malondialdehyde, a marker of oxidative stress and lipid peroxidation. Furthermore, P53 suppression impaired the permeability of the BBB monolayers. In contrast, P53 induction by Nutlin and Hsp90 inhibitor AUY922 enhanced the BBB function. In conclusion, P53 supports BBB integrity, at least in part, by reducing lipid peroxidation. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
