Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 18, Pages 12058-12070Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01994
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- Netherlands Organisation for Scientific Research (NWO)
- Hercules Foundation [AUGE/11/029]
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We report the intramolecular Tsuji-Trost reaction of Ugi adducts to give Spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials.
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