Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 19, Pages 12656-12663Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02031
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Funding
- National Key Research and Development Program of China [2017YFC0210900]
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A general and efficient oxyhalogenation of unsaturated ketoximes has been achieved through copper catalysis with diethyl bromomalonate, N-chlorosuccinimide, and N-iodosuccinimide, yielding 5-chloromethyl, 5-bromomethyl, and 5-iodomethyl isoxazolines in good to excellent yields.
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