Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 20, Pages 13135-13143Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01469
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Funding
- Algeria Ministry of Higher Education and Scientific Research
- ANR [ANR-16-CE07-0001]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE07-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Prochloraz. In the presence of phosphine-free Pd(OAc)(2) catalyst, aryl bromides are efficiently coupled at the CS-position of the imidazole units, which are widely decorated. Under these conditions, only C-H bond arylation reaction occurred without affecting the integrity of chemical structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.
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