Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 334, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2019.576996
Keywords
Exosomes; Adipose-derived stem cells; Microglia; Inflammation; Neural injury
Categories
Funding
- Beijing Municipal Natural Science Foundation [7164261]
- Basics-Clinical Research Cooperation Fund of Capital Medical University [16JL31]
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Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflammation. We found that ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway. Production of inflammatory factors in lipopolysaccharide-stimulated microglia cells decreased significantly when pretreated with ADSC-exosomes. Furthermore, ADSC-exosomes could decrease the cytotoxicity of activated microglia. These results revealed that ADSC-exosomes might be a promising strategy for the therapy of neural injury.
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