Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 9, Pages 2586-2593Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00471
Keywords
-
Funding
- National Natural Science Foundation of China [41576130, U1605221]
- National Key Research and Development Program of China [2018YFC0310901]
- Innovative research team of high-level local universities in Shanghai
- University of Queensland
- Institute for Molecular Bioscience
Ask authors/readers for more resources
Eleven new nitrogenous meroterpenoids, cinerols A-K (1-11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare SH-pyrrolo[1,2a]-benzimidazole moiety, while cinerols C-G (3-7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 mu M; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8-27 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available