Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 9, Pages 2653-2658Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00016
Keywords
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Funding
- Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Natural Science Foundation for Distinguished Young Scholars [81725021]
- National Natural Science Foundation of China [21772048, 81573316, 21602068, 81773597]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Science and Technology Project of China [2018ZX09201001-001-003]
- Natural Science Foundation of Hubei Province of China [2018CFA076, 2018CFA027]
- Academic Frontier Youth Team of HUST
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
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Two cysteine residue containing merocytochalasans (cyschalasins A and B, 1 and 2) and two 17,18-seco-aspochalasins (secochalasins A and B, 3 and 4) were isolated from the endophytic fungus Aspergillus micronesiensis. Cyschalasins A and B represent a new type of merocytochalasan featuring the fusion of an aspochalasin with a modified cysteine residue. Secochalasins A and B are the first 17,18-seco-aspochalasins to be reported and represent a previously undescribed carbon skeleton. Plausible biosynthetic pathways of 1-4 were proposed. Compounds 1 and 2 were cytotoxic and active against Gram-positive bacteria.
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