Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 106, Issue 6, Pages 1313-1323Publisher
WILEY
DOI: 10.1002/JLB.3A0819-171RR
Keywords
IL-10; PD-L1; TGF-beta; NK
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The percentage of human CD56(-)CD16(+) NK cells increases during chronic infection with human HIV; however, the biologic role of CD56(-)CD16(+) NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56(-)CD16(+) NK cells producing IL-10 and TGF-beta was higher than CD56(dim)CD16(+) NK cells. CD56(-)CD16(+) NK cells could inhibit IFN-gamma production by autologous CD8(+) T cells, and this inhibition could be partially reversed by anti-IL-10, anti-TGF-beta, or anti-PD-L1 mAbs. CD56(-)CD16(+) NK cells are potential targets for the development of novel immune therapies against HIV infection.
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