Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 62, Issue 12, Pages 860-864Publisher
WILEY
DOI: 10.1002/jlcr.3802
Keywords
mGlu5 receptors; PET tracers; radiosynthesis; (E)-[C-11]ABP688
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We report an efficient protocol for the radiosynthesis of diastereomerically pure (E)-[C-11]ABP688, a positron emission tomography (PET) tracer for metabotropic glutamate type 5 (mGlu5) receptor imaging. The protocol reliably provides sterile and pyrogen-free formulation of (E)-[C-11]ABP688 suitable for preclinical and clinical PET imaging with >99% diastereomeric excess (d.e.), >99% overall radiochemical purity (RCP), 14.9 +/- 4.3% decay-corrected radiochemical yield (RCY), and 148.86 +/- 79.8 GBq/mu mol molar activity in 40 minutes from the end of bombardment.
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