Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 81, Issue -, Pages 81-87Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2019.08.055
Keywords
Microdroplets; Microparticles; Single emulsion; Microfluidics; Droplet splitting; High throughput
Funding
- National Research Foundation of Korea - Korean Government (KMEST) [NRF-2017R1A2B4004966]
- Project of Advanced Technology Center - Korean Government (MOTIE) [10077414]
- Korea Health Technology R&D Project - Korean Government (MHW) [HI16C1787]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10077414] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we propose a repeated geometrical T-junction breakup microfluidic filter device for fabricating microspheres from premixed emulsions. The proposed microfluidic filter device is composed of multiple repeated T shapes in the microchannel for droplet splitting. Microdroplets are guided along the microchannel and divided symmetrically at the T-junction in the microchannel. The results obtained herein show that as the number of filters was increased, the droplet diameter decreased and the droplet size distribution improved significantly. The behaviors of the microdroplets in the microchannel were inspected as a function of the viscosity of the premixed emulsion solution. The microdroplet diameter increased significantly as the emulsion viscosity increased. Furthermore, the microfluidic filter device was tested by using it to prepare chitosan microspheres. Chitosan microspheres of a narrow size distribution with coefficient value of 6.2% were prepared successfully. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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