Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 56, Issue 9, Pages 2536-2541Publisher
WILEY
DOI: 10.1002/jhet.3648
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LY19C140002]
- Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University [2018GDGP0104]
- Research Fund of Department of Education of Zhejiang Province [Y201840646]
- Opening Foundation of Collaborative Innovation Center of Zhejiang Province Green Pesticide [LSNY201805]
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Nine novel difluoromethylpyrazole acyl urea derivatives were synthesized via seven steps conveniently. All the structures were determined by H-1-NMR, C-13-NMR, HRMS, and X-ray diffraction. The in vivo fungicidal activities were determined against Corynespora mazei, Botrytis cinerea, Fusarium oxysporum, and Pseudomonas syringae, respectively. The bioassay results indicated that some of them displayed good control effective (around 50 and 80%) against P. syringae and B. cinerea at 50 mg/L, respectively, which is better than control. It is possible that difluoromethylpyrazole acyl urea derivatives can be a leading compound for the development of new fungicides against the two fungi with further structure optimization. Furthermore, docking model was studied to establish structure-activity relationship of difluoromethylpyrazole acyl urea derivatives.
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