Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 12, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13045-019-0770-1
Keywords
Cancer-associated fibroblasts; Heterogeneity; Immune suppression; Cancer immunotherapy
Categories
Funding
- National Natural Science Foundation of China [81802277, 81872378]
- China Postdoctoral Science Foundation [2018 M642198]
- Project of Jiangsu Provincial Medical Talent [ZDRCA2016033]
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Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide physical support for tumor cells but also play a key role in promoting and retarding tumorigenesis in a context-dependent manner. CAFs have also been involved in the modulation of many components of the immune system, and recent studies have revealed their roles in immune evasion and poor responses to cancer immunotherapy. In this review, we describe our current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct immune cell types. More importantly, we highlight potential therapeutic strategies that target CAFs to unleash the immune system against the tumor.
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