Related references
Note: Only part of the references are listed.A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
Marcus Schewe et al.
SCIENCE (2019)
Shifts in the selectivity filter dynamics cause modal gating in K+ channels
Shehrazade Jekhmane et al.
NATURE COMMUNICATIONS (2019)
Water and hydrophobic gates in ion channels and nanopores
Shanlin Rao et al.
FARADAY DISCUSSIONS (2018)
Molecular Mechanism of Conductance Enhancement in Narrow Cation-Selective Membrane Channels
Williams E. Miranda et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2018)
Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels
Wojciech Kopec et al.
NATURE CHEMISTRY (2018)
Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel
Ana I. Fernandez-Marino et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Inverted allosteric coupling between activation and inactivation gates in K+ channels
Alain J. Labro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel
Ana I. Fernandez-Marino et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Water and hydrophobic gates in ion channels and nanopores
Shanlin Rao et al.
FARADAY DISCUSSIONS (2018)
Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels
Jing-Xiang Wu et al.
PROTEIN & CELL (2018)
Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel
Jing Li et al.
JOURNAL OF GENERAL PHYSIOLOGY (2018)
Hydrophobic gating in BK channels
Zhiguang Jia et al.
NATURE COMMUNICATIONS (2018)
Anomalous X-ray diffraction studies of ion transport in K+ channels
Patricia S. Langan et al.
NATURE COMMUNICATIONS (2018)
Gating energetics of a voltage-dependent K+ channel pore domain
Greg Starek et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2017)
Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel
Emre Lacin et al.
JOURNAL OF GENERAL PHYSIOLOGY (2017)
Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy
Huong T. Kratochvil et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel
Victor Pau et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
G Protein-Gated Potassium Channels: A Link to Drug Addiction
Robert A. Rifkin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2017)
Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel
Victor Pau et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Molecular structure of human KATP in complex with ATP and ADP
Kenneth Pak Kin Lee et al.
ELIFE (2017)
The gating cycle of a K+ channel at atomic resolution
Luis G. Cuello et al.
ELIFE (2017)
Mechanism of activation at the selectivity filter of the KcsA K+ channel
Florian T Heer et al.
eLife (2017)
Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
Gregory M. Martin et al.
ELIFE (2017)
Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol
Ian W. Glaaser et al.
SCIENTIFIC REPORTS (2017)
A BEST example of channel structure annotation by molecular simulation
Shanlin Rao et al.
CHANNELS (2017)
Structure of a Pancreatic ATP-Sensitive Potassium Channel
Ningning Li et al.
CELL (2017)
Structural dynamics of potassium-channel gating revealed by single-molecule FRET
Shizhen Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Structural dynamics of potassium-channel gating revealed by single-molecule FRET
Shizhen Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
Marcus Schewe et al.
CELL (2016)
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids
Sun-Joo Lee et al.
JOURNAL OF GENERAL PHYSIOLOGY (2016)
Digitalized K+ Occupancy in the Nanocavity Holds and Releases Queues of K+ in a Channel
Takashi Sumikama et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction
Kota Kasahara et al.
PLOS ONE (2016)
Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy
Huong T. Kratochvil et al.
SCIENCE (2016)
Individual Ion Binding Sites in the K+ Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation
Kimberly Matulef et al.
STRUCTURE (2016)
Functional Annotation of Ion Channel Structures by Molecular Simulation
Jemma L. Trick et al.
STRUCTURE (2016)
The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel
Xuan-Yu Meng et al.
SCIENTIFIC REPORTS (2016)
Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels
Weiwei Wang et al.
eLife (2016)
Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation
Luca Conti et al.
SCIENTIFIC REPORTS (2016)
Keppen-Lubinsky Syndrome Is Caused by Mutations in the Inwardly Rectifying K+ Channel Encoded by KCNJ6
Andrea Masotti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2015)
Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels
Tobias Linder et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
Hydrophobic Gating in Ion Channels
Prafulla Aryal et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
Ion-binding properties of a K+ channel selectivity filter in different conformations
Shian Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
K+ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside
Clay M. Armstrong et al.
JOURNAL OF GENERAL PHYSIOLOGY (2014)
Ion permeation in K+ channels occurs by direct Coulomb knock-on
David A. Koepfer et al.
SCIENCE (2014)
Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels
Philip W. Fowler et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)
Atomic-level simulation of current-voltage relationships in single-file ion channels
Morten O. Jensen et al.
JOURNAL OF GENERAL PHYSIOLOGY (2013)
C-type inactivation of voltage-gated K+ channels: Pore constriction or dilation?
Toshinori Hoshi et al.
JOURNAL OF GENERAL PHYSIOLOGY (2013)
NMDA and GABAB (KIR) Conductances: The Perfect Couple for Bistability
Honi Sanders et al.
JOURNAL OF NEUROSCIENCE (2013)
Recovery from slow inactivation in K+ channels is controlled by water molecules
Jared Ostmeyer et al.
NATURE (2013)
X-ray structure of the mammalian GIRK2-βγ G-protein complex
Matthew R. Whorton et al.
NATURE (2013)
Ion Concentration-Dependent Ion Conduction Mechanism of a Voltage-Sensitive Potassium Channel
Kota Kasahara et al.
PLOS ONE (2013)
Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels
Karthik Bodhinathan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels
Sun-Joo Lee et al.
NATURE COMMUNICATIONS (2013)
Probing the Energy Landscape of Activation Gating of the Bacterial Potassium Channel KcsA
Tobias Linder et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
Constant electric field simulations of the membrane potential illustrated with simple systems
James Gumbart et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)
Hinge-bending motions in the pore domain of a bacterial voltage-gated sodium channel
Annika F. Barber et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)
Structural correlates of selectivity and inactivation in potassium channels
Jason G. McCoy et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)
Drying Transition in the Hydrophobic Gate of the GLIC Channel Blocks Ion Conduction
Fangqiang Zhu et al.
BIOPHYSICAL JOURNAL (2012)
The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel
Xuan-Yu Meng et al.
BIOPHYSICAL JOURNAL (2012)
The Solvation Structure of Na+ and K+ in Liquid Water Determined from High Level ab Initio Molecular Dynamics Simulations
Christopher N. Rowley et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Molecular modelling of cation-pi interactions
Guillaume Lamoureux et al.
MOLECULAR SIMULATION (2012)
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
Vassiliy N. Bavro et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Ion Conduction through the hERG Potassium Channel
Luisa Ceccarini et al.
PLOS ONE (2012)
Realistic simulation of the activation of voltage-gated ion channels
Anatoly Dryga et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5
Ute I. Scholl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Exploring conformational states of the bacterial voltage-gated sodium channel NavAb via molecular dynamics simulations
Cristiano Amaral et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mechanism of Voltage Gating in Potassium Channels
Morten O. Jensen et al.
SCIENCE (2012)
Structural rearrangements underlying ligand-gating in Kir channels
Shizhen Wang et al.
NATURE COMMUNICATIONS (2012)
Dual-Mode Phospholipid Regulation of Human Inward Rectifying Potassium Channels
Wayland W. L. Cheng et al.
BIOPHYSICAL JOURNAL (2011)
Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium
Matthew R. Whorton et al.
CELL (2011)
Interactions of Cations with the Cytoplasmic Pores of Inward Rectifier K+ Channels in the Closed State
Atsushi Inanobe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
Scott B. Hansen et al.
NATURE (2011)
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27
Bartosz Balana et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations
Lucie Delemotte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
Murim Choi et al.
SCIENCE (2011)
Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels
Oliver B. Clarke et al.
CELL (2010)
Functional Complementation and Genetic Deletion Studies of KirBac Channels ACTIVATORY MUTATIONS HIGHLIGHT GATING-SENSITIVE DOMAINS
Jennifer J. Paynter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A Structural Determinant for the Control of PIP2 Sensitivity in G Protein-gated Inward Rectifier K+ Channels
Atsushi Inanobe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
g_membed: Efficient Insertion of a Membrane Protein into an Equilibrated Lipid Bilayer with Minimal Perturbation
Maarten G. Wolf et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease
Christian Luescher et al.
NATURE REVIEWS NEUROSCIENCE (2010)
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hiroshi Hibino et al.
PHYSIOLOGICAL REVIEWS (2010)
Principles of conduction and hydrophobic gating in K+ channels
Morten O. Jensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Conformational Changes During the Gating of a Potassium Channel Revealed by Structural Mass Spectrometry
Sayan Gupta et al.
STRUCTURE (2010)
A discrete alcohol pocket involved in GIRK channel activation
Prafulla Aryal et al.
NATURE NEUROSCIENCE (2009)
Atypical mechanism of conduction in potassium channels
Simone Furini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution
Xiao Tao et al.
SCIENCE (2009)
Conformational Changes and Slow Dynamics through Microsecond Polarized Atomistic Molecular Simulation of an Integral Kv1.2 Ion Channel
Par Bjelkmar et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations
Phillip J. Stansfeld et al.
BIOCHEMISTRY (2008)
End-point targeted molecular dynamics: Large-scale conformational changes in potassium channels
R. J. Mashl et al.
BIOPHYSICAL JOURNAL (2008)
The Membrane Potential and its Representation by a Constant Electric Field in Computer Simulations
Benoit Roux
BIOPHYSICAL JOURNAL (2008)
GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation
Berk Hess et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)
Modeling membranes under a transmembrane potential
Lucie Delemotte et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2008)
Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations
In Suk Joung et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2008)
HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures
Bosco K. Ho et al.
BMC STRUCTURAL BIOLOGY (2008)
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera
Motohiko Nishida et al.
EMBO JOURNAL (2007)
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2):: Interaction with other regulatory ligands
Lai-Hua Xie et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2007)
Canonical sampling through velocity rescaling
Giovanni Bussi et al.
JOURNAL OF CHEMICAL PHYSICS (2007)
Comparison of multiple amber force fields and development of improved protein backbone parameters
Viktor Hornak et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
New roles for a key glycine and its neighboring residue in potassium channel gating
Avia Rosenhouse-Dantsker et al.
BIOPHYSICAL JOURNAL (2006)
Dynamics of K+ ion conduction through Kv1.2
Fatemeh Khalili-Araghi et al.
BIOPHYSICAL JOURNAL (2006)
Molecular restraints in the permeation pathway of ion channels
Werner Treptow et al.
BIOPHYSICAL JOURNAL (2006)
Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1
Scott Pegan et al.
BIOCHEMISTRY (2006)
A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor
Oliver Beckstein et al.
PHYSICAL BIOLOGY (2006)
Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN
Ofer Wiser et al.
NEURON (2006)
Molecular determinants of gating at the potassium-channel selectivity filter
JF Cordero-Morales et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Role of aromatic localization in the gating process of a potassium channel
C Domene et al.
BIOPHYSICAL JOURNAL (2006)
Conformational dynamics of M2 helices in KirBac channels: Helix flexibility in relation to gating via molecular dynamics simulations
A Grottesi et al.
BIOCHEMISTRY (2005)
Gβγ-dependent and Gβγ-independent basal activity of G protein-activated K+ channels
I Rishal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons
XX Chen et al.
JOURNAL OF NEUROSCIENCE (2005)
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
S Pegan et al.
NATURE NEUROSCIENCE (2005)
KcsA closed and open: modelling and simulation studies
J Holyoake et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2004)
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of Kir channels by diverse modulators
XO Du et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel
TW Claydon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Ion channel gating: insights via molecular simulations
O Beckstein et al.
FEBS LETTERS (2003)
Potassium channel, ions, and water: Simulation studies based on the high resolution X-ray structure of KcsA
C Domene et al.
BIOPHYSICAL JOURNAL (2003)
New syndrome with generalized lipodystrophy and a distinctive facial appearance: Confirmation of Keppen-Lubinski syndrome?
D De Brasi et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2003)
Structural basis of inward rectification:: Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution
M Nishida et al.
CELL (2002)
Open-state models of a potassium channel
PC Biggin et al.
BIOPHYSICAL JOURNAL (2002)
G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons
M Torrecilla et al.
JOURNAL OF NEUROSCIENCE (2002)
Energetics of ion conduction through the K+ channel
S Bernèche et al.
NATURE (2001)
Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels
W Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel
Y Kubo et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Ion permeation mechanism of the potassium channel
J Åqvist et al.
NATURE (2000)
Heterologous facilitation of G protein-activated K+ channels by β-adrenergic stimulation via cAMP-dependent protein kinase
C Müllner et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)
Share Paper
