Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 216, Issue 11, Pages 2453-2465Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20190545
Keywords
-
Categories
Funding
- National Institutes of Health [AI146855, AI128547, AI067497]
- Norwegian Cancer Society [B05035/001]
- Research Council of Norway (Center of Excellence Funding Scheme) [223255/F50]
Ask authors/readers for more resources
The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1-activating inflammasomes. The related proteins GSDME and GSDMA have also been implicated in autoimmune diseases and certain cancers. Most gasdermin proteins are believed to have pore-forming capabilities. The best-studied member, GSDMD, controls the release of the proinflammatory cytokines IL-1 beta and IL-18 and pyroptotic cell death. Because of its potential as a driver of inflammation in septic shock and autoimmune diseases, GSDMD represents an attractive drug target. In this review, we discuss the gasdermin proteins with particular emphasis on GSDMD and its mechanism of action and biological significance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available