Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 23, Pages 5632-5635Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.10.025
Keywords
Nucleic acid-based therapeutics; Prodrug; Protecting group; Hypoxia; Hybridization
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Funding
- Strategic Research Base Development Program for Private Universities (Kanagawa University) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Takahashi Industrial and Economic Research Foundation
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Oligonucleotides containing 4-O-(4-NO2-benzyl)thymine residues were synthesized to assess potential prodrug-type action against hypoxic cells. These modified oligonucleotides were incapable of stable duplex formation under non-hypoxic conditions. However, following deprotection of the thymine residues under bioreductive conditions, the deprotected oligonucleotides were able to form stable duplexes with target oligonucleotides. (C) 2015 Elsevier Ltd. All rights reserved.
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