Journal
JOURNAL OF CONTROLLED RELEASE
Volume 309, Issue -, Pages 25-36Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2019.07.023
Keywords
Focused ultrasound; Blood-brain barrier; Drug delivery
Funding
- Physicians' Services Incorporated Foundation
- Hold'em for Life Oncology Clinician Scientist program
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The blood-brain barrier, while fundamental in maintaining homeostasis in the central nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved brain penetration is also desirable for reduced dose, cost, and systemic side effects. Transient disruption of the blood-brain barrier with focused ultrasound (FUS) can facilitate drug delivery noninvasively with precise spatial and temporal specificity. FUS technology is transcranial and effective without further drug modifications, key advantages that will accelerate adoption and translation of existing therapeutic pipelines. In this review, we performed a comprehensive literature search to build a database and provide a synthesis of ultrasound parameters and drug characteristics that influence the safety and efficacy profile of FUS to enhance drug delivery.
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