Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 552, Issue -, Pages 388-400Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.05.066
Keywords
Alzheimer's disease; Nanocomposite; Autophagy; A beta
Categories
Funding
- National Natural Science Foundation of China [21701034, 21877051]
- Planned Item of Science and Technology of Guangdong Province [2016A020217011]
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At present, autophagic dysfunction has been considered to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, the activation of autophagy provides a potential means of eliminating the intracellular amyloid-beta (A beta) and slows down the neurotoxicity induced by A beta. Here, we synthesize a Quercetin (Qu) modified polysorbate 80 (P-80)-coated AuPd core-shell structure. Our results indicate that Concave cubic Qu@P-80@AuPd can activate autophagy of SH-SY5Y cells, promote the fusion of autophagosomes and lysosomes, accelerate the clearance of A beta, and protect SH-SY5Y cells from A beta-induced cytotoxicity damage. Furthermore, Concave cubic Qu@P-80@AuPd also has good biocompatibility and high blood-brain barrier (BBB) permeability. Therefore, we anticipate that Concave cubic Qu@P-80@AuPd will be used as a potential autophagy inducer to treat AD. (C) 2019 Elsevier Inc. All rights reserved.
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