Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 24, Pages 5804-5807Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.10.037
Keywords
Onchocerciasis; Biomarker; Metabolomics; Litomosoides sigmodontis; Neurotransmitter
Categories
Funding
- Worm Institute of Research and Medicine (WIRM)
- Skaggs Institute for Chemical Biology
- Institute for Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Germany - Bill and Melinda Gates Foundation [OPP1083888]
- Bill and Melinda Gates Foundation [OPP1083888] Funding Source: Bill and Melinda Gates Foundation
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The neglected tropical disease onchocerciasis affects more than 35 million people worldwide with over 95% in Africa. Disease infection initiates from the filarial parasitic nematode Onchocerca volvulus, which is transmitted by the blackfly vector Simulium sp. carrying infectious L3 larvae. New treatments and diagnostics are required to eradicate this parasitic disease. Herein, we describe that a previously discovered biomarker for onchocerciasis, N-acetyltyramine-O-glucuronide (NATOG) is also present in urine samples of jirds infected with the onchocerciasis model nematode Litomosoides sigmodontis. Increased NATOG values paralleled a progressing infection and demonstrated that quantification of NATOG in this rodent model can be utilized to track its infectivity. Moreover, our findings suggest how NATOG monitoring may be used for evaluating potential drug candidates. (C) 2015 Elsevier Ltd. All rights reserved.
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