Related references
Note: Only part of the references are listed.Multiple binding sites in organic cation transporters require sophisticated procedures to identify interactions of novel drugs
Hermann Koepsell
BIOLOGICAL CHEMISTRY (2019)
Effects of the P-Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4-Way Crossover Drug-Drug Interaction Study in Healthy Subjects
Bayew Tsega Abebe et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2019)
Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium
Birgit Deutsch et al.
MOLECULAR PHARMACEUTICS (2019)
Protein Abundance of Clinically Relevant Drug-Metabolizing Enzymes in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens
Marek Drozdzik et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)
Empirical models for fitting of oral concentration time curves with and without an intravenous reference
Michael Weiss
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2017)
Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine
Marleen Julia Meyer et al.
PLOS ONE (2017)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition
J. Wang
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study
Tanja Dujic et al.
DIABETES CARE (2016)
Trospium chloride is absorbed from two intestinal absorption windows with different permeability in healthy subjects
Tobias Tadken et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)
Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics
David J. Wagner et al.
PHARMACOLOGICAL RESEARCH (2016)
Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study
Tanja Dujic et al.
DIABETES (2015)
Expression of Drug Transporters and Drug Metabolizing Enzymes in the Bladder Urothelium in Man and Affinity of the Bladder Spasmolytic Trospium Chloride to Transporters Likely Involved in Its Pharmacokinetics
Maria Bexten et al.
MOLECULAR PHARMACEUTICS (2015)
Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects
Thierry Wendling et al.
PHARMACEUTICAL RESEARCH (2015)
Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors
Haichuan Duan et al.
DRUG METABOLISM AND DISPOSITION (2015)
Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine
Marek Drozdzik et al.
MOLECULAR PHARMACEUTICS (2014)
Effect of Concomitant Administration of Trospium Chloride Extended Release on the Steady-State Pharmacokinetics of Metformin in Healthy Adults
Michael G. Oefelein et al.
CLINICAL DRUG INVESTIGATION (2013)
Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes
Tianxiang (Kevin) Han et al.
MOLECULAR PHARMACOLOGY (2013)
The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1
Ali R. Saadatmand et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Oxybutynin and trospium are substrates of the human organic cation transporters
Birger Wenge et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2011)
Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder
D. Staskin et al.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2010)
Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms
Henriette E. Meyer Zu Schwabedissen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
Joachim Geyer et al.
DRUG METABOLISM AND DISPOSITION (2009)
Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
Masahiro Tsuda et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Metformin and the intestine
C. J. Bailey et al.
DIABETOLOGIA (2008)
Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
Hermann Koepsell et al.
PHARMACEUTICAL RESEARCH (2007)
Intestinal absorptive transport of the hydrophilic cation ranitidine:: A kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in caco-2 cells
David L. Bourdet et al.
PHARMACEUTICAL RESEARCH (2006)
Saturable absorptive transport of the hydrophilic organic cation ranitidine in caco-2 cells: Role of pH-Dependent organic cation uptake system and p-glycoprotein
David L. Bourdet et al.
PHARMACEUTICAL RESEARCH (2006)
The human intestinal cytochrome P450 pie
MF Paine et al.
DRUG METABOLISM AND DISPOSITION (2006)
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
J Müller et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
DL Bourdet et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter
K Engel et al.
MOLECULAR PHARMACOLOGY (2005)
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
H Tahara et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Trospium chloride for the treatment of overactive bladder with urge incontinence
D Singh-Franco et al.
CLINICAL THERAPEUTICS (2005)
Clinical pharmacokinetics of trospium chloride
O Doroshyenko et al.
CLINICAL PHARMACOKINETICS (2005)
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
DS Wang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Colonic metabolism of ranitidine: implications for its delivery and absorption
AW Basit et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2001)
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
JW Jonker et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)