Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 40, Issue 8, Pages 1672-1684Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X19872564
Keywords
Arterial spin labeling; cerebral blood flow; near-infrared spectroscopy; brain imaging; brain trauma
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Funding
- Canadian Institutes of Health Research
- National Institutes of Neurological Disorders and Stroke [R01-NS082309-01A1, R01-NS060653, P41-EB015893, MFE-146770]
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The purpose of this study was to assess the accuracy of absolute cerebral blood flow (CBF) measurements obtained by dynamic contrast-enhanced (DCE) near-infrared spectroscopy (NIRS) using indocyanine green as a perfusion contrast agent. For validation, CBF was measured independently using the MRI perfusion method arterial spin labeling (ASL). Data were acquired at two sites and under two flow conditions (normocapnia and hypercapnia). Depth sensitivity was enhanced using time-resolved detection, which was demonstrated in a separate set of experiments using a tourniquet to temporally impede scalp blood flow. A strong correlation between CBF measurements from ASL and DCE-NIRS was observed (slope = 0.99 +/- 0.08, y-intercept = -1.7 +/- 7.4 mL/100 g/min, and R-2 = 0.88). Mean difference between the two techniques was 1.9 mL/100 g/min (95% confidence interval ranged from -15 to 19 mL/100g/min and the mean ASL CBF was 75.4 mL/100 g/min). Error analysis showed that structural information and baseline absorption coefficient were needed for optimal CBF reconstruction with DCE-NIRS. This study demonstrated that DCE-NIRS is sensitive to blood flow in the adult brain and can provide accurate CBF measurements with the appropriate modeling techniques.
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