Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 121, Issue 1, Pages 661-671Publisher
WILEY
DOI: 10.1002/jcb.29313
Keywords
competing endogenous RNA; globlastoma multiforme; HAS2-AS1; tumorigenesis
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Funding
- National Key R&D Program of China [2017YFC1308401]
- National Natural Science Foundation of China [81671144, 91746205]
- Tianjin Natural Science Foundation [17JCZDJC36100]
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Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles and its underlying molecular mechanisms still need to be further investigated. In this study, the biological function and potential molecular mechanism of lncHAS2-AS1 in GBM were explored. It was discovered that HAS2-AS1 was elevated in glioma tissues and correlated with the prognosis of patients with glioma. Reduction of HAS2-AS1 suppressed the migration and invasion in vitro and in vivo. The transcription factor STAT1 could raise HAS2-AS1 by binding to its promoter region. Besides, HAS2-AS1 could adjust PRPS1 via sponging miR-608 in a direct manner. On the whole, the results of this study evidence that HAS2-AS1 is an oncogene and a potential therapeutic target for GBM.
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