Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 12, Pages 19345-19357Publisher
WILEY
DOI: 10.1002/jcb.28699
Keywords
esophageal cancer; linc-PINT; miR-543; miR-576-5p; nomogram
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Funding
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM7090]
- Chinese National Science Foundation [81302055]
- Key R&D Program of Shaanxi [2017SF-165]
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This manuscript aimed to investigate linc-PINT's role as a tumor suppressor and its downstream microRNAs (miRNAs) in esophageal cancer. Log-rank, Cox, and nomogram were used for survival analysis. Quantitative real-time polymerase chain reaction was used to evaluate the expression. Cell counting kit-8 was used for proliferation tests. As for in vivo experiments, low expression of linc-PINT was associated with better prognosis; besides, the nomogram indicated that linc-PINT, miR-543, and miR-576-5p served well in predicting the survival rate. As for the in vitro experiments, linc-PINT could directly regulate miR-543 and miR-576-5p to inhibit the proliferation of Eca-109 cell line. In conclusion, linc-PINT-miR-543/miR-576-5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer.
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