Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 15, Issue 9, Pages 1923-1936Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2019.2821
Keywords
Injectable Hydrogel; Breast Cancer; Chemotherapy; Azobenzene; Click Chemistry
Funding
- National Natural Science Fund for Distinguished Young Scholars [NSFC31525009]
- Sichuan Innovative Research Team Program for Young Scientists [2016TD0004]
- Postdoctoral Innovation Talents Support Program [BX20180207]
- China Postdoctoral Science Foundation [2019M653410]
- Post-Doctor Research Project, West China Hospital, Sichuan University [2018HXBH043]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
- National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University [Z2018B06]
- National Natural Science Foundation of China [NSFC31800797]
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Injectable hydrogels possess huge potential as localized drug carriers in breast cancer chemotherapy, owing to several advantages, including easy target administration, enhanced therapeutic efficiency, and less systemic side effects. Herein, we describe an injectable, near-infrared (NIR) light-responsive click cross-linked azobenzene hydrogel (AzoGel) that displays NIR irradiation-mediated smart drug release. The hydrogel can be formed in situ via click cross-linking by mixing two kinds of gelatin derivatives functioned with dibenzylcyclooctyne (DBCO) and azidated azobenzene (N-3-Azo) respectively. The polyacrylic acid (PAA)-coated upconversion nanoparticles (UCNPO PAA)-encapsulated AzoGel has NIR light-responsive characteristics owing to the photoisomerization of azobenzene in the networks. The amount of an anticancer drug doxorubicin (DOX), released from the hydrogel can be efficiently controlled by tuning the exposure time and intensity of 980 nm NIR light. Results of the in vivo study using DOX and UCNP@ PAA-loaded AzoGel controlled by NIR light in the 4T1 breast cancer xenograft mouse model demonstrated an enhanced anti-cancer effect. To conclude, the injectable, NIR light-responsive, click cross-linked AzoGel exhibits a high potential as a localized drug delivery platform for cancer therapy.
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