Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 24, Issue 7, Pages 1077-1085Publisher
SPRINGER
DOI: 10.1007/s00775-019-01718-6
Keywords
Fluorescent sensing and imaging; Hydrogen polysulfides; BODIPY; Near-infrared
Funding
- National Natural Science Foundation of China [21971115, 21501085]
- Key University Science Research Project of Jiangsu Province [17KJA150004]
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Hydrogen polysulfides (H2Sn, n > 1), as the oxidized forms of H2S, have attracted increasing attention these years due to their involvement in signaling transduction and cytoprotective processes. It is necessary to detect H2Sn in living systems for the study of their functions. In this work, we report a BODIPY-based near-infrared emitting fluorescence probe NIR-PHS1, with turn-on response, rapid response rate (within 10 min), outstanding selectivity and excellent sensitivity (detection limit = 12 nM) response towards H2Sn. The probe was successfully applied to the visualizing of endogenous H2Sn in living cells. Moreover, it can be used for near-infrared in vivo imaging of H2Sn in living mice. Therefore, NIR-PHS1 could be a potential imaging tool to study the biological roles of H2Sn in living systems.
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